Singulator 100

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Fast. High Yield. High Viability.

The Singulator™ 100 System

Solid Tissue Dissociation.

The bench-top Singulator System and its single-use cartridges enable reproducible, rapid and hands-off tissue dissociations into single-cell or nuclei suspensions. Its ability to perform cold dissociation minimizes the expression of stress-related genes in cells and helps preserve RNA quality in nuclei. Researchers can now easily obtain suspensions of nuclei or high-viability cells for a wide range of single-cell analyses.

Singulator functions







Minimal Variability. Multiple Applications.

Ideal for genomics, cell biology and other ‘omics applications, including scRNA-Seq, snRNA-Seq, ATAC-Seq, CITE-Seq, FACS, and immuno-oncology. S2 Genomics provides a selection of pre-set protocols and pre-formulated reagents for cell isolations for an expanding set of mouse, rat, and human tissues, including tumors. See the wide range of tissues and organisms demonstrated on the Singulator 100 System here.



Process fresh, frozen and OCT tissues.

CellsFresh20-60 minutes10,000 to >500,000/mg70-95%
NucleiFresh, Frozen, OCT5-1/2 minutes10,000 to >600,000/mgN/A

*Varies depending on tissue types

Nuclei In 7-12 Minutes

Reproducibly generate high-quality suspensions of nuclei from a wide range of tissues.

Singulator 100 System

Merged DAPI-stained and bright-field images of small intestine, brain and heart tissue nuclei; DAPI stained liver nuclei. Courtesy of Dr. Minoda, Laboratory for Cellular Epigenomics, RIKEN Yokohama, Japan.

High Yields From Small Samples

Singulator 100 System

Consistent High Yields of Nuclei

Singulator 100 System

See It In Action

Watch this video to learn how to prepare single-nuclei suspension from mouse kidney tissue on the Singulator 100 System.

Single Cells in 20-60 Minutes

Reproducibly generate suspensions of single cells in high yield with high-viability from a wide range of tissues.

Singulator 100 System

Bright-field images of mouse kidney and spleen tissue cells.

High Cell Yields

Singulator 100 System

High Cell Viabilities

Singulator 100 System

Intuitive Software. Customizable Protocols.

Choose from a selection of pre-set protocols and pre-formulated reagents. Create your own protocols with customizable parameters, including mincing, enzyme incubation time, temperature, mixing and mechanical disruption profile. Optionally, use your own reagents.

Singulator 100 System

1. Select from lists of Standard, Favorites, Recently Run protocols, or create your own protocol with customizable parameters.

Singulator 100 System

Singulator 100 System

2. Enter optional user notes and press RUN.

Singulator 100 System

3. Step-by-step instructions and videos guide you through the system operation.

Singulator 100 System

4. The internal camera and progress bar allow you to monitor tissue dissociation in real time.

Singulator 100 System

Performance At A Glance

The Singulator 100TM System comes with a unique Single-Shot MechanismTM for convenient cell-isolation reagent loading and a Reagent Chiller that stores reagents for up to 100 nuclei runs.

Singulator 100 System

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