Lyo-Ready Direct DNA LAMP and RNA/DNA LAMP Stool mixes are ready-to-use, 4x concentrated, fully optimized mixes for isothermal amplification methods such as loop-mediated isothermal amplification (LAMP) on stool samples, designed to dramatically speed up assay development time and reduce time to results. The glycerol-free mixes contain optimized excipients compatible with freezing and lyophilization, making them ideal for POC stool testing. Can also be used wet and/or with purified nucleic acid.
Lyo-Ready Direct DNA LAMP and RNA/DNA LAMP Stool mixes are ready-to-use, 4x concentrated, fully optimized mixes for isothermal amplification methods such as loop-mediated isothermal amplification (LAMP) on stool samples, designed to dramatically speed up assay development time and reduce time to results. The glycerol-free mixes contain optimized excipients compatible with freezing and lyophilization, making them ideal for POC stool testing. Can also be used wet and/or with purified nucleic acid.
Diarrhoeal disease is the 8th leading cause of death globally and the 2nd leading cause of death in children under the age of five. It is caused by a variety of bacterial, viral and parasitic organisms and is usually spread through the fecal-oral route or by foodborne transmission. Diagnostic tests, especially point-of-care (POC), are essential to enable the rapid identification of gastrointestinal infections and provide the right treatment to prevent serious complications and prevent its spread. Ideally, POC diagnostics are simple to use, involve minimal-to-no-sample pre-processing, do not require cold room storage and are as sensitive and specific as laboratory-based tests. Assays using stool as a specimen can pose a substantial challenge for POC assays as stool samples can be complex, containing food debris, desquamated epithelial cells and mucus, and potential PCR inhibitors such as bile salts, polysaccharides, hematin and catabolic substances. Typically, complex samples require pre-processing to extract the DNA or RNA prior to testing.
The Lyo-Ready Direct DNA LAMP Stool and Lyo-Ready RNA/DNA LAMP Stool mixes combine even greater tolerance with fast, robust isothermal amplification to enable highly sensitive direct detection using crudely processed stool samples. The mixes are uniquely designed to overcome much higher concentrations of inhibitors and so do not require a DNA or RNA purification step to purify a patient sample. Very fast reaction kinetics result in faster time to results and superior amplification sensitivity and specificity. In addition, the 4x concentrated master mixes are formulated with lyo-excipients which are optimized for freeze-drying to create ambient-temperature stable assays, making them ideal for POC stool testing.
Lyo-Ready Direct DNA LAMP Stool, 4x, MDX144
Application: LAMP Specimen Type: Stool, DNA Concentration: 4x High Concentration: Yes Wet: Liquid
Glycerol-Free: Yes Lyo-Ready: Yes Air-Dryable: No Dryable: Lyo-Ready Sustainability: Lyophilizable
Inhibitor tolerance to 20% stool, 2 mg/mL bile salt and 40% Cary Blair media. Perfect for multiplexing and fast cycling conditions. Used in the detection of IBD, cancer, fecal microbiota and bacterial and viruses.
Available in 5 mL (1,000 Rxns) or 50 mL (10,000 Rxns) aliquots
Lyo-Ready Direct RNA/DNA LAMP Stool, 4x, MDX145
Application: RT-LAMP Specimen Type: Stool, RNA Concentration: 4x High Concentration: Yes Wet: Liquid
Glycerol-Free: Yes Lyo-Ready: Yes Air-Dryable: No Dryable: Lyo-Ready Sustainability: Lyophilizable
Inhibitor tolerance to 5% stool, 2 mg/mL bile salt and 40% Cary Blair media. Perfect for multiplexing and fast cycling conditions. Used in the detection of IBD, cancer, fecal microbiota and bacterial and viruses.
Available in 5 mL (1,000 Rxns) or 50 mL (10,000 Rxns) aliquots
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