Urine is an ideal clinical specimen because it is excreted in large quantities, is non-invasive, and it can be self-sampled.
• Ultra-sensitive detection down to less than 1 copy using direct amplification protocols.
• Inhibitor-tolerant to PCR inhibitors found in whole blood, serum, plasma.
• Tight fluorescence cluster with clear allele discrimination, perfect for difficult SNPs.
• Can be used in liquid or lyophilized, ideal for high-throughput or POC testing.
Urine specimens can be used in the early detection of minimal residual disease (MRD) of bladder cancer1 , kidney cancer2, cervical cancer3 and prostate cancer4. However, urine contains substances such as urea and nucleases that can damage DNA or inhibit the PCR reaction. Meridian’s Liquid Biopsy Urine qPCR Mix is unique in that it enables highly sensitive, very fast detection of target DNA directly from high concentrations of urine. Furthermore, this mix can be used in a wet format or lyophilized to create ambient-temperature stable.
1 Tan D, Jiang W, Hu R, Li Z, Ou T. Detection of the ADGRG6 hotspot mutations in urine for bladder cancer early screening by ARMS-qPCR. Cancer Med. 2023 Apr 20. doi: 10.1002/cam4.5879. Epub ahead of print. PMID: 37081791.
2 Arance, E.; Ramírez, V.; Rubio-Roldan, A.; Ocaña-Peinado, F.M.; Romero-Cachinero, C.; Jódar-Reyes, A.B.; Vazquez-Alonso, F.; Martinez-Gonzalez, L.J.; Alvarez-Cubero, M.J. Determination of Exosome Mitochondrial DNA as a Biomarker of Renal Cancer Aggressiveness. Cancers 2022, 14, 199. https://doi.org/10.3390/cancers14010199
3 Snoek, B.C., Splunter, A.P.v., Bleeker, M.C.G. et al. Cervical cancer detection by DNA methylation analysis in urine. Sci Rep 9, 3088 (2019). https://doi.org/10.1038/s41598-019-39275-2
4 Foj L, Milà M, Mengual L, Luque P, Alcaraz A, Jiménez W, Filella X. Real-time PCR PCA3 assay is a useful test measured in urine to improve prostate cancer detection. Clin Chim Acta. 2014 Aug 5;435:53-8. doi: 10.1016/j.cca.2014.04.025. Epub 2014 May 5. PMID: 24803095.
| SKU: | Size: | Reactions: | Webshop |
| ODX004-1 | 1 mL | 200 | Order online |
| ODX004-5 | 5 ml | 1,000 | Order online |
| ODX004-50 | 50 ml | 10,000 | Order online |
Please fill out the following form about your inquiry.
We are experts in Life Science Automation that understand our customers and suppliers. Trust and quality are the basis for the partnerships we form.
